Tuberculosis but not Immune Reconstitution Inflammatory Syndrome (IRIS) prevents early and late NK cell degranulation reconstitution in HIV/TB co-infected patients
نویسندگان
چکیده
Methods (i) 138 HIV+/TB+ patients enrolled in the CAMELIA trial (ANRS 1295-CIPRA/KH001-DAIDS-ES ID10425) in Cambodia and 36 HIV+ patients with CD4 T cells < 200/mm included (ii) NK cells repertoire analysis by immuno-staining in whole blood and, (iii) NK cells degranulation activity and cytokine production by CD107a essay with and without stimulation. After starting of TB therapy in HIV+/TB+ patients, the time points were weeks 2, 8, 14 and 34. Half of the patients started HAART at week 2 and the other half at week 8. The time point of HIV+/TBwere week 0 and 8. The results obtained at baseline and following HAART are presented.
منابع مشابه
Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis.
Immune reconstitution inflammatory syndrome (IRIS) is a common and potentially serious complication occurring in HIV-infected patients being treated for tuberculosis (TB) using combined antiretroviral treatment. A role of adaptive immunity has been suggested in the onset of IRIS, whereas the role of natural killer (NK) cells has not yet been explored. The present study sought to examine the inv...
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